After the death of Ordas and Martinez, and after Orellana, who was employed by Gonzalo Pizarro, one Pedro de Orsua, a knight of Navarre, attempted Guiana, taking his way into Peru, and built his brigandines upon a river called Oia, which riseth to the southward of Quito, and is very great. This river falleth into Amazons, by which Orsua with his companies descended, and came out of that province which is called Motilones ("friars"--Indians so named from their cropped heads); and it seemeth to me that this empire is reserved for her Majesty and the English nation, by reason of the hard success which all these and other Spaniards found in attempting the same, whereof I will speak briefly, though impertinent in some sort to my purpose. This Pedro de Orsua had among his troops a Biscayan called Aguirre, a man meanly born, who bare no other office than a sergeant or alferez (al-faris, Arab.--horseman, mounted officer): but after certain months, when the soldiers were grieved with travels and consumed with famine, and that no entrance could be found by the branches or body of Amazons, this Aguirre raised a mutiny, of which he made himself the head, and so prevailed as he put Orsua to the sword and all his followers, taking on him the whole charge and commandment, with a purpose not only to make himself emperor of Guiana, but also of Peru and of all that side of the West Indies. He had of his party 700 soldiers, and of those many promised to draw in other captains and companies, to deliver up towns and forts in Peru; but neither finding by the said river any passage into Guiana, nor any possibility to return towards Peru by the same Amazons, by reason that the descent of the river made so great a current, he was enforced to disemboque at the mouth of the said Amazons, which cannot be less than 1,000 leagues from the place where they embarked. From thence he coasted the land till he arrived at Margarita to the north of Mompatar, which is at this day called Puerto de Tyranno, for that he there slew Don Juan de Villa Andreda, Governor of Margarita, who was father to Don Juan Sarmiento, Governor of Margarita when Sir John Burgh landed there and attempted the island.
Aguirre put to the sword all other in the island that refused to be of his party, and took with him certain cimarrones (fugitive slaves) and other desperate companions. From thence he went to Cumana and there slew the governor, and dealt in all as at Margarita. He spoiled all the coast of Caracas and the province of Venezuela and of Rio de la Hacha; and, as I remember, it was the same year that Sir John Hawkins sailed to St. Juan de Ullua in the Jesus of Lubeck; for himself told me that he met with such a one upon the coast, that rebelled, and had sailed down all the river of Amazons. Aguirre from thence landed about Santa Marta and sacked it also, putting to death so many as refused to be his followers, purposing to invade Nuevo Reyno de Granada and to sack Pamplona, Merida, Lagrita, Tunja, and the rest of the cities of Nuevo Reyno, and from thence again to enter Peru; but in a fight in the said Nuevo Reyno he was overthrown, and, finding no way to escape, he first put to the sword his own children, foretelling them that they should not live to be defamed or upbraided by the Spaniards after his death, who would have termed them the children of a traitor or tyrant; and that, sithence he could not make them princes, he would yet deliver them from shame and reproach. These were the ends and tragedies of Ordas, Martinez, Orellana, Orsua, and Aguirre. Also soon after Ordas followed Jeronimo Ortal de Saragosa, with 130 soldiers; who failing his entrance by sea, was cast with the current on the coast of Paria, and peopled about S. Miguel de Neveri. It was then attempted by Don Pedro de Silva, a Portuguese of the family of Ruy Gomez de Silva, and by the favour which Ruy Gomez had with the king he was set out. But he also shot wide of the mark; for being departed from Spain with his fleet, he entered by Maranon or Amazons, where by the nations of the river and by the Amazons, he was utterly overthrown, and himself and all his army defeated; only seven escaped, and of those but two returned.
After him came Pedro Hernandez de Serpa, and landed at Cumana, in the West Indies, taking his journey by land towards Orenoque, which may be some 120 leagues; but ere he came to the borders of the said river, he was set upon by a nation of the Indians, called Wikiri, and overthrown in such sort, that of 300 soldiers, horsemen, many Indians, and negroes, there returned but eighteen. Others affirm that he was defeated in the very entrance of Guiana, at the first civil town of the empire called Macureguarai. Captain Preston, in taking Santiago de Leon (which was by him and his companies very resolutely performed, being a great town, and far within the land) held a gentleman prisoner, who died in his ship, that was one of the company of Hernandez de Serpa, and saved among those that escaped; who witnessed what opinion is held among the Spaniards thereabouts of the great riches of Guiana, and El Dorado, the city of Inga. Another Spaniard was brought aboard me by Captain Preston, who told me in the hearing of himself and divers other gentlemen, that he met with Berreo's campmaster at Caracas, when he came from the borders of Guiana, and that he saw with him forty of most pure plates of gold, curiously wrought, and swords of Guiana decked and inlaid with gold, feathers garnished with gold, and divers rarities, which he carried to the Spanish king.